ABSTRACT
Xeroderma pigmentosum [XP] is a rare form of genodermatosis, characterized by cutaneous pigmentary changes, sensitivity to light and development of multiple cutaneous and internal malignancies at an early age as a result of nucleotide excision repair defect after ultraviolet light exposure. Cutaneous angiosarcomas are angry neoplasms that are rarely associated with XP. In this communication, we report the case of a 22-year-old male patient with XP who developed an angiosarcoma of the face and a basosquamous carcinoma at one time. It is probably the first such case reported from Pakistan
ABSTRACT
Keratinocytic tumours of epidermis constitute the bulk of neoplastic lesions of the skin, and comprise benign, borderline and malignant lesions. To study the characteristics of keratinocytic turnours in our hospital population and compare the collected local data with the available international data. This cross-sectional, descriptive study was conducted in University of Health Science and Mayo Hospital, Lahore from March 2010 to October 2010. A total of 112 consecutive cases of histologically diagnosed keratinocytic tumours were included in the study. Age, gender, histologic types and site distribution of these tumours were recorded and analyzed. Among keratinocytic tumours, basal and squamous cell carcinomas were the most frequent malignant lesions and viral warts were the commonest benign lesion. Males were affected more commonly than females. Patients were in the age range of 13-85 years. Head and neck region was the most frequent site of involvement. The results of the study are comparable with international data regarding age, gender and site distribution of keratinocytic tumours.